The multi-tasking protein FMRP wires mammalian brain

The Algebra of Multi-tasking

Modelling multi-tasking behaviour is an important phase of real-time system design. It is shown how task scheduling principles can be captured in a CCS-based process algebra via extensions for both asymmetric interleaving, to model intraprocessor scheduling decisions, and for asynchronous communication, to model interprocessor precedence constraints. Examples are given of task preemption, block...

FXR1P but not FMRP regulates the levels of mammalian brain-specific microRNA-9 and microRNA-124.

Mammalian brain-specific miR-9 and miR-124 have been implicated in several aspects of neuronal development and function. However, it is not known how their expression levels are regulated in vivo. We found that the levels of miR-9 and miR-124 are regulated by FXR1P but not by the loss of FXR2P or FMRP in vivo, a mouse model of fragile X syndrome. Surprisingly, the levels of miR-9 and miR-124 ar...

Multi-tasking for TinyOS

Tasks in TinyOS execute non-preemptively and run to completion, forcing programmers to keep individual tasks short and spread lengthy operations across multiple tasks – a major divergence from conventional programming paradigms. This report documents our attempt to incorporate multi-tasking into TinyOS and its subsequent effect on power consumption of “motes”. We succeeded in modifying the Tiny...

Contests with multi-tasking

A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain

Deregulation of synaptic plasticity may contribute to the pathogenesis of developmental cognitive disorders. In particular, exaggerated mGluR-dependent LTD is featured in fragile X syndrome, but the mechanisms that regulate mGluR-LTD remain incompletely understood. We report that conditional knockout of Cdh1, the key regulatory subunit of the ubiquitin ligase Cdh1-anaphase-promoting complex (Cd...